Membranes as Therapeutic Targets

By Lukas Buehler, Ph.D.

Membrane proteins function as gateways between cells and their surroundings. Molecular transport, energy conversion, and receptor signaling are the major mechanism of action. Due to their importance in physiology and cell surface location, membrane proteins are preeminent therapeutic targets for the treatment of metabolic, immunological, vascular, endocrinological and neurological disorders and prevention of viral infections. In this course, students will gain an understanding of the structure-function relationship of membrane proteins (e.g. ion channels, transporters, G-protein coupled receptors, tyrosine kinase receptors, and membrane bound enzymes) in health and diseases. This course requires basic knowledge of proteins and the biology of the cell.

Internet Resources

Genes and Diseases

Online Mendelian Inheritance in Man

both at the National Center for Biotechnology Information (NCBI)

eMedicine Clinical Knowledge Base with coverage of 7,000 diseases and disorders Kinemage - Download your own visualization software package
Kinemage Supplement to Branden and Tooze by J.S. Richardson and D.C. Richardson, Garland Publishing Co., NY ISBN: 0815333269 / CD-ROM


Molecular Biology of Membrane Transport Disorders, by Stanley G. Schultz (Editor)

Plenum Pub Corp; 2nd edition (July 1996);
ISBN: 0306451646
Price: $238

Cell Physiology Source Book
by Nicholas Sperelakis

Academic Press; ISBN: 0126569770
Paperback - 1235 pages 3rd ed. (September 2001)
Price: $79.95 

(This lecture has been developed for UCSD Extension, Bioscience Program)

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